Esketamine Treatment
A new generation of care for individuals who haven’t found relief through traditional antidepressants
What is Esketamine Treatment and when is it considered?
Esketamine is a promising therapy for adults with treatment-resistant Depression—especially where other medications haven’t provided enough symptom relief. Delivered as a clinically supervised nasal spray, Esketamine can offer rapid mood improvement, often within days.
At Fullarton Clinic, we provide Esketamine Treatment in a safe, purpose-built hospital environment as part of a personalised mental health treatment plan. Our multidisciplinary team includes Psychiatrists, Nurses, and Allied Health professionals who will guide you through every step of your care.
Esketamine may be suitable when:
- At least two previous antidepressants have been ineffective
- Traditional medications have caused difficult side effects
- A quick response is needed due to the severity of Depression
- There’s a preference for a new treatment approach
- Suicidal thoughts are present, and immediate relief is required
A Psychiatrist will assess your symptoms, medical history, and previous treatments to determine whether Esketamine is appropriate for you.
What to Expect with Esketamine Treatment
Esketamine is typically administered twice per week during the initial phase of treatment, followed by a gradual reduction in frequency based on your response and treatment plan.
Duration and intensity may vary depending on your clinical needs and your Psychiatrist’s recommendation.
- Mode: Nasal spray (Spravato®), administered under supervision
- Frequency: Typically twice weekly for the first month, then weekly or fortnightly as maintenance
- Supervision: Always given in a clinical setting with trained staff present
- Adjunctive Care: Given alongside a newly prescribed oral antidepressant
Our team of specialists will closely monitor your response, ensuring your wellbeing, safety, and optimal outcomes.

Your treating Psychiatrist will carefully assess your suitability and talk you through potential risks and benefits.

Safety and Side Effects
Esketamine is administered in a clinical setting under the supervision of specialists to ensure your safety during the treatment process.
As with any medication, some side effects may occur. These are typically mild and short lived but may include:
- Dizziness or light-headedness
- Nausea
- Drowsiness or fatigue
- Increased blood pressure (temporary)
- Feeling disconnected or dissociated shortly after treatment
These effects usually resolve within a few hours. Patients remain under observation following each treatment session to ensure safety and wellbeing before returning home.
Maintaining Wellness and Safety, With You in Control
Your care doesn’t end after a single phase of treatment — we continue to support your progress with options that respect your needs and preferences.
Esketamine is administered in a calm, private setting within our hospital, providing immediate support if needed. Patients remain under observation for a short period after each session to ensure comfort and safety.
Esketamine is often part of a broader treatment plan, including Inpatient Treatment, Counselling, medications, or Day Programs to support long term wellness.
At Fullarton Clinic, your care is guided by informed choice. Our team is here to answer your questions, explain all available options, and ensure you feel informed, supported, and respected throughout your treatment.

